5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate

Base Information

Chemical Name:5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate
CAS No.:1416790-87-8
Molecular Formula:C₂₀H₂₅F₃N₂O₅S₂
Molecular Weight:494.556
Hs Code.:

Synonyms:5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate

Suppliers and Price of 5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of 5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate

There total 2 articles about 5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1416790-86-7
C₁₀H₁₉NOS

: 163936-42-3
trifluoromethanesulfonic acid 2-phenyl-oxazol-4-yl ester

: 1416790-87-8
5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate

Guidance literature:: trifluoromethanesulfonic acid 2-phenyl-oxazol-4-yl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 70 ℃; for 0.166667h;

C₁₀H₁₉NOS; In tetrahydrofuran; hexane; at -78 ℃; stereoselective reaction;
DOI:10.1021/jo301856f

Reference yield:

: 30216-01-4
2-phenyl-2-oxazolin-4-one

: 1416790-87-8
5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 - 70 °C

2.2: -78 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo301856f

Reference yield:

: 1416790-87-8
5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate

: 1416790-88-9,1036931-36-8,1996616-36-4,394735-23-0,1036931-35-7
(2R)-4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-aminium chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 4 h / 0 °C

2: isopropyl alcohol; water / 2 h / 20 °C

With water; sodium hydroxide; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jo301856f