30216-01-4

Basic information

• Product Name: 4(5H)-Oxazolone, 2-phenyl-
• CAS NO: 30216-01-4
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Mol File: 30216-01-4.mol

Chemical Properties

• CAS DataBase Reference: 4(5H)-Oxazolone, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(5H)-Oxazolone, 2-phenyl-(30216-01-4)
• EPA Substance Registry System: 4(5H)-Oxazolone, 2-phenyl-(30216-01-4)

Safety Data

• Hazardous Substances Data: 30216-01-4(Hazardous Substances Data)

Upstream product

• 7218-27-1 N-(2-chloroethanoyl)benzamide 
• 4461-33-0 benzoyl isocyanate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 55-21-0 benzamide 
• 186581-53-3 diazomethane 
• 3315-16-0 silver cyanate 
• 98-88-4 benzoyl chloride 
• 107-14-2 chloroacetonitrile 
• 65-85-0 benzoic acid 
• 5816-79-5 benzoylcarbamoyl azide 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 38789-30-9 6,6-dimethoxy-5-phenyl-4-oxa-1-aza-bicyclo[3.2.0]heptan-2-one 
• 1426444-51-0 5-(bromomethyl)-1,3-diphenyl-1H-1,2,4-triazole 
• 87905-22-4 2-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)acetonitrile 
• 1426444-52-1 2-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)ethanamine 
• 1426444-60-1 (3-phenyl-1-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)methanol 
• 1416790-98-1 5-[1-[(tert-butylsulfinyl)amino]-2,2-dimethylpropyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate 
• 1416790-97-0 5-[1-[(tert-butylsulfinyl)amino]-3-methylbutyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate 
• 1416790-96-9 5-[1-[(tert-butylsulfinyl)amino]pentyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate 
• 1416790-95-8 5-[[(tert-butylsulfinyl)amino](cyclohexyl)methyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate 
• 1416790-94-7 4-[[(tert-butylsulfinyl)amino](cyclopentyl)methyl]-2-phenyl-1,3-oxazol-5-yl trifluoromethanesulfonate 
• 1416790-87-8 5-[1-[(tert-butylsulfinyl)amino]-2-cyclobutylethyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate 
• 1416791-03-1 5-[[(tert-butylsulfinyl)amino](4-fluorophenyl)methyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate 
• 1416791-02-0 5-[(4-bromophenyl)[(tert-butylsulfinyl)amino]methyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate 
• 1416791-01-9 5-[[(tert-butylsulfinyl)amino](phenyl)methyl]-2-phenyl-1,3-oxazol-4-yl trifluoromethanesulfonate 

Relevant articles and documents

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

Facile one-pot synthesis of di- and tri-substituted furans from acyl isocyanates using trimethylsilyldiazomethane

The Diels-Alder reaction of 2-substituted 4-(trimethylsilyloxy)oxazoles, which were prepared in situ from trimethylsilyldiazomethane and acyl isocyanates, with dimethyl acetylenedicarboxylate or ethyl propiolate gave furan-3,4-dicarboxylic or furan-3-carboxylic esters in good yields.

Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: Synthesis of disubstituted heterocycles

(Matrix presented) This paper describes Sonogashira cross-coupling of functionalized 2-, 4-, and 5-trifloyl oxazoles and thiazoles with terminal alkynes. This methodology has been extended to 2,4-ditrifloylthiazoles, which results in regioselective cross-coupling at the C2-position of the thiazole. The resulting 2-alkynyl-4-trifloylthiazoles are effective electrophiles in a second palladium(0)-mediated cross-coupling reaction.

Facile assembly of 2,4-orthogonally-functionalized oxazoles: Useful bidirectional linchpins

Development of a facile synthesis of 2,4-disubstituted oxazoles, useful 2,4-orthogonally-functionalized oxazole linchpins, has been achieved.