5-<4-(p-Toluenesulfonyloxy)butynyl>-3',5'-di-O-p-toluyl-2'-deoxyuridine

Base Information

Chemical Name:5-<4-(p-Toluenesulfonyloxy)butynyl>-3',5'-di-O-p-toluyl-2'-deoxyuridine
CAS No.:85267-66-9
Molecular Formula:C₃₆H₃₄N₂O₁₀S
Molecular Weight:686.739
Hs Code.:

Synonyms:5-<4-(p-Toluenesulfonyloxy)butynyl>-3',5'-di-O-p-toluyl-2'-deoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<4-(p-Toluenesulfonyloxy)butynyl>-3',5'-di-O-p-toluyl-2'-deoxyuridine

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Technology Process of 5-<4-(p-Toluenesulfonyloxy)butynyl>-3',5'-di-O-p-toluyl-2'-deoxyuridine

There total 3 articles about 5-<4-(p-Toluenesulfonyloxy)butynyl>-3',5'-di-O-p-toluyl-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 85267-65-8
5-(4-Hydroxybutynyl)-3',5'-di-O-p-toluyl-2'-deoxyuridine

: 98-59-9
p-toluenesulfonyl chloride

: 85267-66-9
5-<4-(p-Toluenesulfonyloxy)butynyl>-3',5'-di-O-p-toluyl-2'-deoxyuridine

Guidance literature:: With pyridine; at 25 ℃; for 18h;
DOI:10.1021/jo00159a012

Reference yield:

: 31356-86-2
1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodouracil

: 85267-66-9
5-<4-(p-Toluenesulfonyloxy)butynyl>-3',5'-di-O-p-toluyl-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Et₃N / (Ph₃P)2PdCl₂, CuI / 4 h / 50 °C

2: 90 percent / CF₃COOH / CH₂Cl₂; methanol / 1.5 h / 25 °C

3: 65 percent / pyridine / 18 h / 25 °C

With pyridine; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In methanol; dichloromethane;
DOI:10.1021/jo00159a012

Reference yield:

: 77875-94-6
C₃₄H₃₆N₂O₉

: 85267-66-9
5-<4-(p-Toluenesulfonyloxy)butynyl>-3',5'-di-O-p-toluyl-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / CF₃COOH / CH₂Cl₂; methanol / 1.5 h / 25 °C

2: 65 percent / pyridine / 18 h / 25 °C

With pyridine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jo00159a012