N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide

Base Information

Chemical Name:N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide
CAS No.:638165-63-6
Molecular Formula:C₂₆H₄₀N₂O₄S
Molecular Weight:476.681
Hs Code.:

Synonyms:N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide

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Chemical Property of N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide

Chemical Property:

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Technology Process of N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide

There total 4 articles about N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 638165-62-5
N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide

: 638165-63-6
N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/j.tet.2003.04.001

Reference yield:

: 159525-90-3
N,N’-sulfonyl bis-L-leucine dimethyl ester

: 638165-63-6
N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / K₂CO₃ / acetonitrile / 24 h / Heating

2: 100 percent / LAH / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.tet.2003.04.001

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 638165-63-6
N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; sulfuryl dichloride / dichloromethane / Inert atmosphere

2: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sulfuryl dichloride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/acsmedchemlett.0c00460