N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide

Base Information

• Chemical Name: N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide
• CAS No.: 638165-62-5
• Molecular Formula: C₂₈H₄₀N₂O₆S
• Molecular Weight: 532.701

Synonyms:N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide

Chemical Property of N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide

Chemical Property:

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Technology Process of N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide

There total 2 articles about N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl bromide (100-39-0) + N,N’-sulfonyl bis-L-leucine dimethyl ester (159525-90-3) → N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide (638165-62-5)

Guidance literature:

With potassium carbonate; In acetonitrile; for 24h; Heating;

DOI:10.1016/j.tet.2003.04.001

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide (638165-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; sulfuryl dichloride / dichloromethane / Inert atmosphere

2: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Reflux

With sulfuryl dichloride; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/acsmedchemlett.0c00460

Reference yield: 100.0%

N,N'-bis-benzyl-N-N'-bis-[(1S)-1-(2-methylpropyl)-2-methoxycarbonyl]sulfamide (638165-62-5) → N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide (638165-63-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1016/j.tet.2003.04.001

upstream raw materials:

benzyl bromide

N,N’-sulfonyl bis-L-leucine dimethyl ester

methyl (L)-leucinate hydrochloride

Downstream raw materials:

N,N'-bis-benzyl-N,N'-bis-[(1S)-2-hydroxy-1-(2-methylpropyl)ethyl]-sulfamide

(3S,6S)-2,7-dibenzyl-3,6-diisobutyl-2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxide

C₂₆H₃₆N₂O₄S

N,N'-bis-benzyl-N,N'-bis-[(1S)-1-(2-methylpropyl)-2-propenyl]-sulfamide

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