(4-methylpiperazin-1-yl)(3-{[5-methyl-3-(3-{4-[(trifluoromethyl)sulfanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)methanone

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Chemical Name:(4-methylpiperazin-1-yl)(3-{[5-methyl-3-(3-{4-[(trifluoromethyl)sulfanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)methanone
CAS No.:1227159-32-1
Molecular Formula:C₂₆H₂₅F₃N₆O₂S
Molecular Weight:542.585
Hs Code.:

Synonyms:(4-methylpiperazin-1-yl)(3-{[5-methyl-3-(3-{4-[(trifluoromethyl)sulfanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)methanone

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Chemical Property of (4-methylpiperazin-1-yl)(3-{[5-methyl-3-(3-{4-[(trifluoromethyl)sulfanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)methanone

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Technology Process of (4-methylpiperazin-1-yl)(3-{[5-methyl-3-(3-{4-[(trifluoromethyl)sulfanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)methanone

There total 6 articles about (4-methylpiperazin-1-yl)(3-{[5-methyl-3-(3-{4-[(trifluoromethyl)sulfanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1085453-81-1
N'-hydroxy-4-[(trifluoromethyl)sulphanyl]benzenecarboximidamide

: 1225380-88-0
5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboxylic acid

: 1227159-32-1
(4-methylpiperazin-1-yl)(3-{[5-methyl-3-(3-{4-[(trifluoromethyl)sulfanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)methanone

Guidance literature:: 5-methyl-1-{3-[(4-methylpiperazin-1-yl)carbonyl]benzyl}-1H-pyrazole-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N'-hydroxy-4-[(trifluoromethyl)sulphanyl]benzenecarboximidamide; In N,N-dimethyl-formamide; at 20 - 140 ℃; for 2h;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1227159-32-1
(4-methylpiperazin-1-yl)(3-{[5-methyl-3-(3-{4-[(trifluoromethyl)sulfanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 16 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / Inert atmosphere

3.2: 16 h / 20 °C

4.1: sodium hydroxide / ethanol / 2 h / 70 °C

4.2: pH Ca_.4

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 2 h / 20 - 140 °C

With oxalyl dichloride; potassium tert-butylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1225380-89-1
ethyl 1-[3-(tert-butoxycarbonyl)benzyl]-5-methyl-1H-pyrazole-3-carboxylate

: 1227159-32-1
(4-methylpiperazin-1-yl)(3-{[5-methyl-3-(3-{4-[(trifluoromethyl)sulfanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / Inert atmosphere

2.2: 16 h / 20 °C

3.1: sodium hydroxide / ethanol / 2 h / 70 °C

3.2: pH Ca_.4

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 2 h / 20 - 140 °C

With oxalyl dichloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;