5-fluoropropylepidepride

Base Information

Chemical Name:5-fluoropropylepidepride
CAS No.:126247-33-4
Molecular Formula:C19H29FN2O3
Molecular Weight:352.44
Hs Code.:
Mol file:126247-33-4.mol

Synonyms:N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide;5-Fluoropropylepidepride;Benzamide,N-[[(2S)-1-ethyl-2-pyrrolidinyl]- methyl]-5-(3-fluoropropyl)-2,3-dimethoxy-;Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxy-, (S)-;5-Fprepid;FPMP;

Suppliers and Price of 5-fluoropropylepidepride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 5-fluoropropylepidepride

Chemical Property:

Vapor Pressure:5.62E-08mmHg at 25°C
Refractive Index:1.506
Boiling Point:441°C at 760 mmHg
Flash Point:220.5°C
PSA：54.29000
Density:1.081g/cm³
LogP:3.33270

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-fluoropropylepidepride

There total 11 articles about 5-fluoropropylepidepride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 22795-99-9
(S)-2-(Aminomethyl)-1-ethylpyrrolidine

: 136565-41-8
5-(3-Fluoro-propyl)-2,3-dimethoxy-benzoyl chloride

: 126247-33-4
FPMP

Guidance literature:: In dichloromethane; for 0.25h; Ambient temperature;
DOI:10.1021/jm00109a013

Reference yield:

: 877-22-5
3-methoxysalicylic acid

: 126247-33-4
FPMP

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / 18 M H₂SO₄ / 58 h / Heating

2: 93 percent / K₂CO₃ / acetone / 12 h / Heating

3: 92 percent / 0.75 h

4: 95 percent / K₂CO₃ / acetone / 17 h / Heating

5: 1.) 9-borabicyclo<3.3.1>nonane (9-BBN), 2.) 1 M NaOH, 30percent aq. H₂O₂ / 1.) THF, a) 0 deg C, 40 min, b) RT, 40 min, 2.) a) 0 deg C, 30 min, b) RT, 30 min

6: 83 percent / pyridine / CH₂Cl₂ / 24 h / 2 °C

7: 90 percent / n-Bu₄NF / tetrahydrofuran / 1.5 h

8: 100 percent / 0.5 M aq. NaOH / tetrahydrofuran / 40 h

9: (COCl)2, DMF / CH₂Cl₂ / 0.5 h / 0 °C

10: 90 percent / CH₂Cl₂ / 0.25 h / Ambient temperature

With pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; sulfuric acid; tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jm00109a013

Reference yield:

: 6342-70-7
3-methoxymethylsalicylate

: 126247-33-4
FPMP

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / K₂CO₃ / acetone / 12 h / Heating

2: 92 percent / 0.75 h

3: 95 percent / K₂CO₃ / acetone / 17 h / Heating

4: 1.) 9-borabicyclo<3.3.1>nonane (9-BBN), 2.) 1 M NaOH, 30percent aq. H₂O₂ / 1.) THF, a) 0 deg C, 40 min, b) RT, 40 min, 2.) a) 0 deg C, 30 min, b) RT, 30 min

5: 83 percent / pyridine / CH₂Cl₂ / 24 h / 2 °C

6: 90 percent / n-Bu₄NF / tetrahydrofuran / 1.5 h

7: 100 percent / 0.5 M aq. NaOH / tetrahydrofuran / 40 h

8: (COCl)2, DMF / CH₂Cl₂ / 0.5 h / 0 °C

9: 90 percent / CH₂Cl₂ / 0.25 h / Ambient temperature

With pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jm00109a013