6342-70-7Relevant articles and documents
Phosphorescence at Low Temperature by External Heavy-Atom Effect in Zinc(II) Clusters
Kobayashi, Fumiya,Ohtani, Ryo,Teraoka, Saki,Yoshida, Masaki,Kato, Masako,Zhang, Yingjie,Lindoy, Leonard F.,Hayami, Shinya,Nakamura, Masaaki
, p. 5875 - 5879 (2019)
Luminescent ZnII clusters [Zn4L4(μ3-OMe)2X2] (X=SCN (1), Cl (2), Br (3)) and [Zn7L6(μ3-OMe)2(μ3-OH)4]Y2 (Y=I? (4), ClO4? (5)), HL=methyl-3-methoxysalicylate, exhibiting blue fluorescence at room temperature (λmax=416≈429 nm, Φem=0.09–0.36) have been synthesised and investigated in detail. In one case the external heavy-atom effect (EHE) arising the presence of iodide counter anions yielded phosphorescence with a long emission lifetime (λmax=520 nm, τ=95.3 ms) at 77 K. Single-crystal X-ray structural analysis and time-dependent density-functional theory (TD-DFT) calculations revealed that their emission origin was attributed to the fluorescence from the singlet ligand-centred (1LC) excited state, and the phosphorescence observed in 4 was caused by the EHE of counter anions having strong CH?I interactions.
Evaluation of novel N′-(3-hydroxybenzoyl)-2-oxo-2H-chromene-3-carbohydrazide derivatives as potential HIV-1 integrase inhibitors
Jesumoroti, Omobolanle J.,Faridoon,Mnkandhla, Dumisani,Isaacs, Michelle,Hoppe, Heinrich C.,Klein, Rosalyn
, p. 80 - 88 (2019/01/30)
In an attempt to identify potential new agents that are active against HIV-1 IN, a series of novel coumarin-3-carbohydrazide derivatives were designed and synthesised. The toxicity profiles of these compounds showed that they were non-toxic to human cells and they exhibited promising anti-HIV-1 IN activities with IC50 values in nM range. Also, an accompanying molecular modeling study showed that the compounds bind to the active pocket of the enzyme.
Chromatography-free, Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids to 3-hydroxybenzisoxazoles
Van Eker, Daniel,Chauhan, Jay,Murphy, William A.,Conlon, Ivie L.,Fletcher, Steven
, p. 5301 - 5303 (2016/11/16)
The Mitsunobu reaction has become one of the most powerful tools to alkylate acidic pronucleophiles. A significant caveat of Mitsunobu chemistry, however, is that the reaction mixture is often plagued with purification problems owing to the phosphine oxide and hydrazine dicarboxylate by-products. In addition to the development of more readily separable Mitsunobu reagents, the product's physicochemical properties may be exploited to facilitate purification. In this regard, we present a swift and efficient preparation of 3-hydroxybenzisoxazoles by the Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids, which can be isolated by an acid–base work-up. As expected, a range of functional groups was compatible with the chemistry.
