Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate

Base Information

• Chemical Name: Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate
• CAS No.: 164254-39-1
• Molecular Formula: C₁₄H₁₆N₂O₅
• Molecular Weight: 292.291
• Mol file: 164254-39-1.mol

Synonyms:Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate

Chemical Property of Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate

There total 2 articles about Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate (164254-18-6) → Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate (164254-39-1)

Guidance literature:

With barium permanganate; In dichloromethane; for 44h; Heating;

DOI:10.1021/jo00097a042 DOI:10.1021/jo990136j

Reference yield:

2-(dimethoxymethyl)benzaldehyde (132233-84-2) → Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate (164254-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran; hexane / 2 h / -78 °C

2: BaMnO₄ / CH₂Cl₂ / 44 h / Heating

With barium permanganate; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo00097a042 DOI:10.1021/jo990136j

Reference yield: 53.0%

Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate (164254-39-1) → Ethyl 2-diazo-3-(2-formylphenyl)-3-oxopropionate (164254-15-3)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1021/jo990136j

upstream raw materials:

Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate

2-(dimethoxymethyl)benzaldehyde

Downstream raw materials:

Ethyl 2-diazo-3-(2-formylphenyl)-3-oxopropionate

Ethyl 8-oxo-3-phenyl-3a,8-dihydro-3H-indeno<1,2-d><1,2,3>triazole-8a-carboxylate

(Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate

(E)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate