Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate

Base Information

• Chemical Name: Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate
• CAS No.: 164254-18-6
• Molecular Formula: C₁₄H₁₈N₂O₅
• Molecular Weight: 294.307
• Mol file: 164254-18-6.mol

Synonyms:Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate

Chemical Property of Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate

There total 1 articles about Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + 2-(dimethoxymethyl)benzaldehyde (132233-84-2) → Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate (164254-18-6)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

DOI:10.1021/jo00097a042 DOI:10.1021/jo990136j

Reference yield:

Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate (164254-18-6) → Ethyl 1-oxo-3-(phenylamino)-1H-indene-2-carboxylate

Guidance literature:

Multi-step reaction with 4 steps

1: BaMnO₄ / CH₂Cl₂ / 44 h / Heating

2: 10percent aq. HCl, silica gel / CH₂Cl₂ / 3 h / Ambient temperature

3: MgSO₄ / diethyl ether / 20 h / Ambient temperature

4: 25 percent / rhodium(II) acetate / CHCl₃ / 2 h / 61 °C

With hydrogenchloride; barium permanganate; silica gel; magnesium sulfate; rhodium(II) acetate; In diethyl ether; dichloromethane; chloroform;

DOI:10.1021/jo00097a042

Reference yield:

Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-hydroxypropionate (164254-18-6) → Ethyl 6-oxo-1-phenyl-1a,6-dihydro-1H-1-azacyclopropindene-6a-carboxylate

Guidance literature:

Multi-step reaction with 5 steps

1: BaMnO₄ / CH₂Cl₂ / 44 h / Heating

2: 10percent aq. HCl, silica gel / CH₂Cl₂ / 3 h / Ambient temperature

3: MgSO₄ / diethyl ether / 20 h / Ambient temperature

4: 92 percent / rhodium(II) acetate / CHCl₃ / 24 h / 45 °C

5: 95 percent / rhodium(II) acetate / benzene / 40 h / 80 °C

With hydrogenchloride; barium permanganate; silica gel; magnesium sulfate; rhodium(II) acetate; In diethyl ether; dichloromethane; chloroform; benzene;

DOI:10.1021/jo00097a042

upstream raw materials:

diazoacetic acid ethyl ester

2-(dimethoxymethyl)benzaldehyde

Downstream raw materials:

Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate

Ethyl 2-diazo-3-(2-formylphenyl)-3-oxopropionate

Ethyl 8-oxo-3-phenyl-3a,8-dihydro-3H-indeno<1,2-d><1,2,3>triazole-8a-carboxylate

(Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate