(+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

Base Information

Chemical Name:(+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione
CAS No.:478659-23-3
Molecular Formula:C₁₉H₁₇N₃O₂
Molecular Weight:319.363
Hs Code.:

Synonyms:(+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

Suppliers and Price of (+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

There total 4 articles about (+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 478659-17-5
(+)-(3S)-3-benzyl-5-ethoxy-1-methyl-3,6-dihydro-1H-2-pyrazinone

: 478659-23-3
(+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

Guidance literature:: at 120 ℃; for 3h;
DOI:10.1016/S0040-4020(02)00619-1

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 478659-23-3
(+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide / CH₂Cl₂ / 20 °C

2: 80 percent / 4 h / 200 °C

3: 60 percent / sodium carbonate / CH₂Cl₂ / 20 °C

4: 97 percent / 3 h / 120 °C

With sodium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/S0040-4020(02)00619-1

Reference yield:

: 59017-01-5
(-)-(3S)-3-benzyl-1-methyl-2,5-piperazinedione

: 478659-23-3
(+)-(4S)-4-benzyl-2-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / sodium carbonate / CH₂Cl₂ / 20 °C

2: 97 percent / 3 h / 120 °C

With sodium carbonate; In dichloromethane;
DOI:10.1016/S0040-4020(02)00619-1