N-(5-(4-(cyclohexylthio)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide

Base Information

Chemical Name:N-(5-(4-(cyclohexylthio)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide
CAS No.:1400667-92-6
Molecular Formula:C₂₄H₂₃N₅O₂S₂
Molecular Weight:477.611
Hs Code.:

Synonyms:N-(5-(4-(cyclohexylthio)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide

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Chemical Property of N-(5-(4-(cyclohexylthio)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide

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Technology Process of N-(5-(4-(cyclohexylthio)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide

There total 9 articles about N-(5-(4-(cyclohexylthio)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1083326-28-6
N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-benzenesulfonamide

: 1400668-15-6
6-chloro-4-(cyclohexylthio)pyrido[3,2-d]pyrimidine

: 1400667-92-6
N-(5-(4-(cyclohexylthio)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: With sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 110 ℃; for 1h; Microwave irradiation;

Reference yield:

: 93683-65-9
6-chloro-3-nitropicolinonitrile

: 1400667-92-6
N-(5-(4-(cyclohexylthio)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide; water / 0.33 h / 20 °C

1.2: 3 h / 20 °C

2.1: 3 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 1 h / 20 - 110 °C

4.1: potassium carbonate / acetonitrile / 20 °C

5.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

With ammonium hydroxide; water; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; acetonitrile;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1400667-92-6
N-(5-(4-(cyclohexylthio)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 0.67 h / 0 - 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 100 °C

3: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

With pyridine; potassium acetate; sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water;