[2-(2,6-dichloro-4-cyano-phenyl)-thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

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Chemical Name:[2-(2,6-dichloro-4-cyano-phenyl)-thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester
CAS No.:1365992-25-1
Molecular Formula:C₁₈H₁₄Cl₂N₄O₂S
Molecular Weight:421.307
Hs Code.:

Synonyms:[2-(2,6-dichloro-4-cyano-phenyl)-thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

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Chemical Property of [2-(2,6-dichloro-4-cyano-phenyl)-thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

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Technology Process of [2-(2,6-dichloro-4-cyano-phenyl)-thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

There total 8 articles about [2-(2,6-dichloro-4-cyano-phenyl)-thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 4248-19-5
tert-butyl carbazate

: 1365992-05-7
4-(4-bromo-thiazolo[5,4-c]pyridine-2-yl)-3,5-dichloro-benzonitrile

: 1365992-25-1
[2-(2,6-dichloro-4-cyano-phenyl)-thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In water; toluene; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365992-25-1
[2-(2,6-dichloro-4-cyano-phenyl)-thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

3.2: 18 h

4.1: thionyl chloride / 18 h / Reflux

5.1: thiourea; pyridine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

5.2: 6.5 h / Reflux

6.1: trimethylsilyl bromide / propiononitrile / 48 h / 90 °C

7.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 80 °C / Inert atmosphere

With pyridine; potassium phosphate; thionyl chloride; trimethylsilyl bromide; diphenyl phosphoryl azide; sodium hydride; thiourea; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; toluene; propiononitrile; mineral oil;

Reference yield:

: 1258298-06-4
2,6-dichloro-4-cyanobenzoyl chloride

: 1365992-25-1
[2-(2,6-dichloro-4-cyano-phenyl)-thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

1.2: 18 h

2.1: thionyl chloride / 18 h / Reflux

3.1: thiourea; pyridine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

3.2: 6.5 h / Reflux

4.1: trimethylsilyl bromide / propiononitrile / 48 h / 90 °C

5.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 80 °C / Inert atmosphere

With pyridine; potassium phosphate; thionyl chloride; trimethylsilyl bromide; sodium hydride; thiourea; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; water; isopropyl alcohol; toluene; propiononitrile; mineral oil;