Technology Process of 2-((3-benzyloxy-4-methoxy)phenyl)-6-bromo-7-methoxychroman
There total 6 articles about 2-((3-benzyloxy-4-methoxy)phenyl)-6-bromo-7-methoxychroman which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
p-toluenesulfonic acid immobilized on silica;
In
toluene;
at 0 - 20 ℃;
DOI:10.1021/jo900504y
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / ethanol / 2 h / 0 - 20 °C
2: dmap; triethylamine / dichloromethane / 20 °C / Cooling with ice
3: p-toluenesulfonic acid on sillica gel / toluene / 0 - 20 °C
With
dmap; sodium tetrahydroborate; p-toluenesulfonic acid on sillica gel; triethylamine;
In
ethanol; dichloromethane; toluene;
3: Diels-Alder reaction;
DOI:10.1016/j.tet.2011.03.059
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bromine; acetic acid / 1 h / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C
2.2: 2 h / 0 - 20 °C
3.1: sodium tetrahydroborate / ethanol / 2 h / 0 - 20 °C
4.1: dmap; triethylamine / dichloromethane / 20 °C / Cooling with ice
5.1: p-toluenesulfonic acid on sillica gel / toluene / 0 - 20 °C
With
dmap; sodium tetrahydroborate; p-toluenesulfonic acid on sillica gel; bromine; sodium hydride; acetic acid; triethylamine;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
5.1: Diels-Alder reaction;
DOI:10.1016/j.tet.2011.03.059