1153673-79-0

Upstream product

• 57543-36-9 5-bromo-2-hydroxy-4-methoxybenzaldehyde 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 1153674-06-6 5-bromo-4-methoxy-2-methoxymethyloxybenzyl alcohol 
• 75-36-5 acetyl chloride 

Downstream Products

• 1153673-83-6 6-bromo-7-methoxy-2-phenylchroman 
• 1153673-84-7 2-((3-benzyloxy-4-methoxy)phenyl)-6-bromo-7-methoxychroman 
• 1311271-18-7 6-bromo-7-methoxy-2-(4-methoxyphenyl)chroman 
• 1417423-40-5 4-bromo-5-methoxy-2-(2,4,5-trimethoxybenzyl)phenol 
• 1417423-38-1 4-bromo-5-methoxy-2-(2,4,6-trimethoxybenzyl)phenol 
• 1417423-50-7 4-bromo-5-methoxy-2-((2-methoxynaphthalen-1-yl)methyl)phenol 
• 1417423-39-2 4-bromo-2-(2,4-dimethoxybenzyl)-5-methoxyphenol 

Relevant academic research and scientific papers

Pt(IV)-catalyzed generation and [4+2]-cycloaddition reactions of o-quinone methides

Novel intermolecular and intramolecular generations of ortho-quinone methides and their formal [4+2]-cycloaddition reactions with olefins catalyzed by PtCl4 and AuCl3 under mild conditions have been developed. Good to excellent yields (up to 99%) and diastereoselectivity (up to >99:1) of the chromans were obtained. PtCl4 was found to be effective and compatible with various functional groups present in the substrates. A mechanism accounting for its catalytic cycle is proposed and discussed.

Generation of ortho-quinone methides by p-TsOH on silica and their hetero-Diels-Alder reactions with styrenes

(Chemical Equation Presented) 2-Arylchromans were readily prepared from the hetero-Diels-Alder reactions of styrenes with the ortho-quinone methides (o-QMs) which, in turn, were generated by treating the MOM-protected benzylacetate derivatives with p-TsOH immobilized on silica (PTS-Si) in toluene under mild conditions (0°C to rt). The corresponding chromans were obtained in moderate to excellent yields (42-97%) and in moderate to excellent diastereoselectivity (up to >99:1).