(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl methyl ester

Base Information

Chemical Name:(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl methyl ester
CAS No.:84520-85-4
Molecular Formula:C₂₀H₂₈N₂O₅
Molecular Weight:376.453
Hs Code.:

Synonyms:(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl methyl ester

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Chemical Property of (4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl methyl ester

Chemical Property:

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Technology Process of (4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl methyl ester

There total 5 articles about (4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 84520-78-5
(4S)-1-benzoyl-4-<(carboxymethyl)amino>-L-proline 4-tert-butyl methyl ester

: 84520-85-4
(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl methyl ester

Guidance literature:: With sodium cyanoborohydride; In acetonitrile; for 0.25h; Ambient temperature;
DOI:10.1021/jm00358a017

Reference yield:

: 84520-72-9
(4S)-1-benzoyl-1-azido-L-proline methyl ester

: 84520-85-4
(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: concd. HCl, H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

2: dioxane; dimethylformamide / 48 h / 50 °C

3: 75 percent / NaBH₃CN / acetonitrile / 0.25 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00358a017

Reference yield:

: 65-85-0,8013-63-6
benzoic acid

: 84520-85-4
(4S)-1-benzoyl-4-<(carboxymethyl)methylamino>-L-proline 4-tert-butyl methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: DCC / 48 h

2: concd. HCl, H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

3: dioxane; dimethylformamide / 48 h / 50 °C

4: 75 percent / NaBH₃CN / acetonitrile / 0.25 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium cyanoborohydride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00358a017