ethyl 1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Base Information

• Chemical Name: ethyl 1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate
• CAS No.: 1616491-55-4
• Molecular Formula: C₁₉H₁₅FN₂O₅
• Molecular Weight: 370.337

Synonyms:ethyl 1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Chemical Property of ethyl 1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Chemical Property:

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Technology Process of ethyl 1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

There total 10 articles about ethyl 1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-Fluorobenzyl bromide (459-46-1) + ethyl 6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (103514-53-0,175087-43-1) → ethyl 1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1616491-55-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1021/acs.jmedchem.1c00535

Reference yield: 84.0%

C19H16F2N2O5 → ethyl 1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1616491-55-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.666667h;

DOI:10.1016/j.bmc.2014.05.028

Reference yield:

ethyl 6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (103514-53-0,175087-43-1) → ethyl 1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1616491-55-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Reflux;

DOI:10.1016/j.ejmech.2021.113207

upstream raw materials:

ethyl (E)-3-(dimethylamino)acrylate

2-fluoro-5-nitrobenzoic acid

2-fluoro-5-nitrobenzoyl chloride

4-Fluorobenzyl bromide

Downstream raw materials:

methyl 2-(3-(1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxamido)propoxy)-6-hydroxybenzoate

1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

6-amino-1-(4-fluorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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