di(t-butyl) 2-[((1-(chloromethyl)-3-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl)sulfonyl)amino]ethyl phosphate

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Chemical Name:di(t-butyl) 2-[((1-(chloromethyl)-3-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl)sulfonyl)amino]ethyl phosphate
CAS No.:1292298-06-6
Molecular Formula:C₃₃H₄₁ClN₃O₁₀PS
Molecular Weight:738.195
Hs Code.:

Synonyms:di(t-butyl) 2-[((1-(chloromethyl)-3-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl)sulfonyl)amino]ethyl phosphate

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Chemical Property of di(t-butyl) 2-[((1-(chloromethyl)-3-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl)sulfonyl)amino]ethyl phosphate

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Technology Process of di(t-butyl) 2-[((1-(chloromethyl)-3-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl)sulfonyl)amino]ethyl phosphate

There total 4 articles about di(t-butyl) 2-[((1-(chloromethyl)-3-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl)sulfonyl)amino]ethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 885228-16-0
di(t-butyl) 2-(([1-(chloromethyl)-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl]sulfonyl)amino)ethyl phosphate

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 1292298-06-6
di(t-butyl) 2-[((1-(chloromethyl)-3-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl)sulfonyl)amino]ethyl phosphate

Guidance literature:: di(t-butyl) 2-(([1-(chloromethyl)-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl]sulfonyl)amino)ethyl phosphate; (E)-3-(4-methoxyphenyl)acrylic acid; With toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ISOPROPYLAMIDE; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In ISOPROPYLAMIDE; water; Cooling;
DOI:10.1002/anie.201004456

Reference yield:

: 885228-14-8
benzyl (2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamate

: 1292298-06-6
di(t-butyl) 2-[((1-(chloromethyl)-3-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl)sulfonyl)amino]ethyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 5% Pd(II)/C(eggshell); hydrogen / methanol / 2.5 h / 2585.81 Torr

2.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

2.2: 0.42 h

3.1: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / ISOPROPYLAMIDE / 4 h / 20 °C

3.2: Cooling

With 5% Pd(II)/C(eggshell); hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; ISOPROPYLAMIDE;
DOI:10.1002/anie.201004456

Reference yield:

: 137348-86-8
di-tert-butyl diisopropylphosphoramide

: 1292298-06-6
di(t-butyl) 2-[((1-(chloromethyl)-3-[(2E)-3-(4-methoxyphenyl)-2-propenoyl]-5-nitro-1,2-dihydro-3H-benzo[e]indol-7-yl)sulfonyl)amino]ethyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-tetrazole / tetrahydrofuran; acetonitrile / 16 h / 20 °C

1.2: 6.25 h / 0 °C

2.1: 5% Pd(II)/C(eggshell); hydrogen / methanol / 2.5 h / 2585.81 Torr

3.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

3.2: 0.42 h

4.1: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / ISOPROPYLAMIDE / 4 h / 20 °C

4.2: Cooling

With 1H-tetrazole; 5% Pd(II)/C(eggshell); hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; acetonitrile;
DOI:10.1002/anie.201004456