(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex

Base Information

Chemical Name:(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex
CAS No.:1313508-66-5
Molecular Formula:C₁₀H₁₅NO*C₂₃H₁₉N₃O₂
Molecular Weight:534.658
Hs Code.:

Synonyms:(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex

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Chemical Property of (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex

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Technology Process of (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex

There total 6 articles about (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1000873-98-2,1239986-50-5
(±)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 1313508-66-5
(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex

Guidance literature:: In methanol; water; at 0.55 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 1313508-66-5
(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert-butyl methyl ether / 2.17 h / 15 - 32 °C / Industry scale

1.2: 2 h / Industry scale

2.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 - 32 °C / Industry scale

2.2: 0.5 h / 40 - 50 °C / Industry scale

2.3: 40 °C / pH 8 - 9 / Industry scale

3.1: hydrogen; potassium tert-butylate / 20 % Pd(OH)2/C / tetrahydrofuran / 45 - 55 °C / 3361.55 - 4137.29 Torr / Industry scale

4.1: hydrogenchloride / water; Isopropyl acetate / Industry scale

5.1: acetonitrile / 50 °C

With hydrogenchloride; potassium tert-butylate; hydrogen; 20 % Pd(OH)2/C; In tetrahydrofuran; tert-butyl methyl ether; Isopropyl acetate; water; acetonitrile;

Reference yield:

: 345264-02-0
(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

: 1313508-66-5
(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 - 32 °C / Industry scale

1.2: 0.5 h / 40 - 50 °C / Industry scale

1.3: 40 °C / pH 8 - 9 / Industry scale

2.1: hydrogen; potassium tert-butylate / 20 % Pd(OH)2/C / tetrahydrofuran / 45 - 55 °C / 3361.55 - 4137.29 Torr / Industry scale

3.1: hydrogenchloride / water; Isopropyl acetate / Industry scale

4.1: acetonitrile / 50 °C

With hydrogenchloride; potassium tert-butylate; hydrogen; 20 % Pd(OH)2/C; In tetrahydrofuran; Isopropyl acetate; water; acetonitrile;