diethyl 2-(4'-benzyloxyphenyl)malonate

Base Information

• Chemical Name: diethyl 2-(4'-benzyloxyphenyl)malonate
• CAS No.: 24220-48-2
• Molecular Formula: C₂₀H₂₂O₅
• Molecular Weight: 342.392
• Mol file: 24220-48-2.mol

Synonyms:diethyl 2-(4'-benzyloxyphenyl)malonate

Chemical Property of diethyl 2-(4'-benzyloxyphenyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of diethyl 2-(4'-benzyloxyphenyl)malonate

There total 1 articles about diethyl 2-(4'-benzyloxyphenyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ diethyl 2-(4'-benzyloxyphenyl)malonate (24220-48-2)

Guidance literature:

aus (p-Benzyloxy-phenyl)-essigsaeureaethylester und Diaethylcarbonat in Ggw. von Na-Hydrid;

DOI:10.1021/ja01036a055

Reference yield:

diethyl 2-(4'-benzyloxyphenyl)malonate (24220-48-2) → 2-[4-(benzyloxy)phenyl]-1,3-propanediol (155062-29-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; for 6h;

DOI:10.1016/j.bmc.2008.06.050

Reference yield:

diethyl 2-(4'-benzyloxyphenyl)malonate (24220-48-2) → 5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole (1258604-33-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

4.1: potassium carbonate / ISOPROPYLAMIDE / 2 h / -20 - -10 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 27 °C / Cooling with ice

With sodium tetrahydroborate; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; toluene;

Downstream raw materials:

5-isopropyl-5-(4'-benzyloxyphenyl)barbituric acid

2-[4-(benzyloxy)phenyl]-1,3-propanediol

5-(4-(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxane

4-(2,2-dimethyl-1,3-dioxan-5-yl)phenol