5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

Base Information

Chemical Name:5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole
CAS No.:1258604-33-9
Molecular Formula:C₂₆H₃₂N₆O₆
Molecular Weight:524.577
Hs Code.:

Synonyms:5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

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Chemical Property of 5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

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Technology Process of 5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

There total 5 articles about 5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-isopropyl-5-(piperidin-4-yl)-1,2,4-oxadiazole hydrochloride salt

: 1258604-32-8
4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine

: 1258604-33-9
5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 27 ℃; for 4h;

Reference yield:

: 24220-48-2
diethyl 2-(4'-benzyloxyphenyl)malonate

: 1258604-33-9
5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

4.1: potassium carbonate / ISOPROPYLAMIDE / 2 h / -20 - -10 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 27 °C / Cooling with ice

With sodium tetrahydroborate; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; toluene;

Reference yield:

: 56441-69-1
2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

: 1258604-33-9
5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / THF (tetrahydrofuran) / 19 h / 0 - 30 °C

2.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

2.2: Cooling with ice

3.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

4.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

5.1: potassium carbonate / ISOPROPYLAMIDE / 2 h / -20 - -10 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 27 °C / Cooling with ice

With sodium tetrahydroborate; ammonium formate; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; toluene;