tert-butyl 3-hydrazinyl-3-oxopropylcarbaMate

Base Information

• Chemical Name: tert-butyl 3-hydrazinyl-3-oxopropylcarbaMate
• CAS No.: 42116-56-3
• Molecular Formula: C₈H₁₇N₃O₃
• Molecular Weight: 203.241
• Mol file: 42116-56-3.mol

Synonyms:(2-hydrazinocarbonyl-ethyl)-carbamic acid tert-butyl ester

Chemical Property of tert-butyl 3-hydrazinyl-3-oxopropylcarbaMate

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl (3-hydrazino-3-oxopropyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Boc-β-alanine Hydrazide is used in the synthesis of GABAA receptor agonists to treat various disorders.

Technology Process of tert-butyl 3-hydrazinyl-3-oxopropylcarbaMate

There total 5 articles about tert-butyl 3-hydrazinyl-3-oxopropylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-tert-butoxycarbonylamino-propionic acid ethyl ester (88574-53-2) → (2-hydrazinocarbonyl-ethyl)-carbamic acid tert-butyl ester (42116-56-3)

Guidance literature:

With hydrazine; In ethanol; for 10h; Reflux;

DOI:10.1016/j.tetlet.2019.151089

Reference yield: 82.0%

3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) → (2-hydrazinocarbonyl-ethyl)-carbamic acid tert-butyl ester (42116-56-3)

Guidance literature:

With hydrazine; In ethanol; for 24h; Heating / reflux;

Reference yield:

methyl 3-tert-butoxycarbonylaminopropionate (42116-55-2) → (2-hydrazinocarbonyl-ethyl)-carbamic acid tert-butyl ester (42116-56-3)

Guidance literature:

With hydrazine hydrate; In methanol; at 70 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.08.099

upstream raw materials:

3-(tert-butyloxycarbonylamino)propionic acid

N-(tert-butyloxycarbonyl) azide

methyl 3-aminopropanoate

3-tert-butoxycarbonylamino-propionic acid ethyl ester

Downstream raw materials:

[2-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamic acid tert-butyl ester

C₂₈H₃₈N₆O₆