2-(4-fluorophenyl)-5-methyl-1H-indole

Base Information

• Chemical Name: 2-(4-fluorophenyl)-5-methyl-1H-indole
• CAS No.: 76609-18-2
• Molecular Formula: C₁₅H₁₂FN
• Molecular Weight: 225.265
• Mol file: 76609-18-2.mol

Synonyms:5-methyl-2-(4'-fluoro)phenyl-1H-indole

Chemical Property of 2-(4-fluorophenyl)-5-methyl-1H-indole

Chemical Property:

Purity/Quality:

2-(4-FLUOROPHENYL)-5-METHYL-1H-INDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)-5-methyl-1H-indole

There total 15 articles about 2-(4-fluorophenyl)-5-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(dimethyl(oxo)- λ6-sulfanylidene)-1-(4-fluorophenyl)ethan-1-one + p-toluidine (106-49-0,12221-03-3) → 5-methyl-2-(4'-fluoro)phenyl-1H-indole (76609-18-2)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; toluene-4-sulfonic acid; In toluene; at 140 ℃; for 0.75h; Microwave irradiation;

DOI:10.1002/anie.201610520

Reference yield: 85.0%

3-(4-fluorophenyl)-2-cyanooxirane (556053-57-7,556053-67-9) + p-toluidine (106-49-0,12221-03-3) → 5-methyl-2-(4'-fluoro)phenyl-1H-indole (76609-18-2)

Guidance literature:

With boron trifluoride diethyl etherate; In ethanol; 2,2,2-trifluoroethanol; for 20h; Reflux;

Reference yield: 77.0%

2-bromo-p-toluidine (583-68-6) + 1-(4-fluorophenyl)ethanone (403-42-9) → 5-methyl-2-(4'-fluoro)phenyl-1H-indole (76609-18-2)

Guidance literature:

With [(IPr)Pd(acac)Cl]; potassium tert-butylate; magnesium sulfate; In toluene; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1002/aoc.1793

upstream raw materials:

1-(2-(4-fluorophenyl)-2-oxoethyl)pyridine-1-ium bromide

p-toluidine

2-bromo-4'-fluoroacetophenone

2-bromo-p-toluidine