tert-butyl (5-(((3S)-4-(4-(1-(azidomethyl)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Base Information

Chemical Name:tert-butyl (5-(((3S)-4-(4-(1-(azidomethyl)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate
CAS No.:1572928-71-2
Molecular Formula:C₂₆H₃₀F₃N₇O₅S
Molecular Weight:609.629
Hs Code.:

Synonyms:tert-butyl (5-(((3S)-4-(4-(1-(azidomethyl)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Chemical Property of tert-butyl (5-(((3S)-4-(4-(1-(azidomethyl)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Technology Process of tert-butyl (5-(((3S)-4-(4-(1-(azidomethyl)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

There total 19 articles about tert-butyl (5-(((3S)-4-(4-(1-(azidomethyl)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-04-1
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1572928-71-2
tert-butyl (5-(((3S)-4-(4-(1-(azidomethyl)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: With sodium azide; ammonium chloride; In methanol; dichloromethane; at 60 ℃; for 20h;

Reference yield:

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 1572928-71-2
tert-butyl (5-(((3S)-4-(4-(1-(azidomethyl)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / 20 °C

1.2: 2 h / 20 °C

2.1: osmium(VIII) oxide / acetone / 6 h / 20 °C

3.1: toluene-4-sulfonic acid / acetone / 40 h / 20 °C

4.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

5.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 1.5 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 20 °C

7.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

8.1: sodium azide; ammonium chloride / dichloromethane; methanol / 20 h / 60 °C

With osmium(VIII) oxide; n-butyllithium; sodium azide; trifluorormethanesulfonic acid; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); ammonium chloride; toluene-4-sulfonic acid; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetone;

Reference yield:

: 1450620-16-2
tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate

: 1572928-71-2
tert-butyl (5-(((3S)-4-(4-(1-(azidomethyl)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

3: sodium azide; ammonium chloride / dichloromethane; methanol / 20 h / 60 °C

With sodium azide; ammonium chloride; triethylamine; p-toluenesulfonyl chloride; In methanol; dichloromethane;