tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Base Information

Chemical Name:tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate
CAS No.:1572928-04-1
Molecular Formula:C₂₆H₂₉F₃N₄O₅S
Molecular Weight:566.601
Hs Code.:

Synonyms:tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Chemical Property of tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Technology Process of tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

There total 20 articles about tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1572928-03-0
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1572928-04-1
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: With p-toluenesulfonyl chloride; trifluoroacetic acid; In dichloromethane; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm5000497

Reference yield:

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 1572928-04-1
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.67 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: water / 1,4-dioxane / 24 h / 85 °C

3.1: toluene-4-sulfonic acid / acetone / 40 h / 20 °C

4.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

5.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 1.5 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 20 °C

7.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

With trifluorormethanesulfonic acid; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium tert-butylate; water; toluene-4-sulfonic acid; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; sodium t-butanolate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; acetone;

Reference yield:

: 1450620-16-2
tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate

: 1572928-04-1
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

With triethylamine; p-toluenesulfonyl chloride; In dichloromethane;