tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate

Base Information

Chemical Name:tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate
CAS No.:1123622-45-6
Molecular Formula:C₂₇H₃₁ClN₂O₃
Molecular Weight:467.008
Hs Code.:

Synonyms:tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate

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Chemical Property of tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate

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Technology Process of tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate

There total 6 articles about tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 934622-50-1
tert-butyl (E)-3-(3-formylphenyl)acrylate

: 952281-84-4
1-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-ethanone

: 1123622-45-6
tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate

Guidance literature:: With potassium hydroxide; In ethanol; water; at 0 ℃; for 7h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1123622-45-6
tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 100 °C

2: potassium hydroxide / ethanol; water / 7 h / 0 °C

With potassium hydroxide; sodium hydrogencarbonate; triethylamine; palladium diacetate; triphenylphosphine; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1123622-45-6
tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 100 °C

2: potassium hydroxide / ethanol; water / 7 h / 0 °C

With potassium hydroxide; sodium hydrogencarbonate; triethylamine; palladium diacetate; triphenylphosphine; In ethanol; water; N,N-dimethyl-formamide;