(E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-N-hydroxy-acrylamide hydrochloride

Base Information

Chemical Name:(E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-N-hydroxy-acrylamide hydrochloride
CAS No.:1123623-02-8
Molecular Formula:C₂₃H₂₄ClN₃O₃*ClH
Molecular Weight:462.376
Hs Code.:

Synonyms:(E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-N-hydroxy-acrylamide hydrochloride

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Chemical Property of (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-N-hydroxy-acrylamide hydrochloride

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Technology Process of (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-N-hydroxy-acrylamide hydrochloride

There total 6 articles about (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-N-hydroxy-acrylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1123622-45-6
tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate

: 1123623-02-8
(E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-N-hydroxy-acrylamide hydrochloride

Guidance literature:: tert-butyl (E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

With O-2-tetrahydro-2H-pyranhydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

With hydrogenchloride; In diethyl ether; dichloromethane; for 4h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1123623-02-8
(E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-N-hydroxy-acrylamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 100 °C

2.1: potassium hydroxide / ethanol; water / 7 h / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

3.2: 20 °C

3.3: 4 h

With potassium hydroxide; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; palladium diacetate; triphenylphosphine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1123623-02-8
(E)-3-(3-{(E)-3-[3-chloro-5-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-N-hydroxy-acrylamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 100 °C

2.1: diethyl ether; toluene / 4 h / 80 °C

2.2: 0.5 h / 20 °C

3.1: potassium hydroxide / ethanol; water / 7 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

4.2: 20 °C

4.3: 4 h

With potassium hydroxide; potassium carbonate; trifluoroacetic acid; In diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;