3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol

Base Information

Chemical Name:3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol
CAS No.:1450621-11-0
Molecular Formula:C₂₁H₁₈BrF₆N₃O₄S
Molecular Weight:602.352
Hs Code.:

Synonyms:3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol

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Chemical Property of 3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol

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Technology Process of 3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol

There total 15 articles about 3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450621-12-1
C₂₁H₁₇BrClF₆N₃O₃S

: 1450621-10-9
2-(4-((2S)-4-((6-amino-5-bromo-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1450621-11-0
3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol

Guidance literature:: With ammonium hydroxide; In ethanol; water; at 115 ℃;

Reference yield:

: 1450620-14-0
4-benzyl 1-tert-butyl 2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

: 1450621-11-0
3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol

Guidance literature:: Multi-step reaction with 6 steps

1: Chiralpak^? ADH column / ethanol / Resolution of racemate

2: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

3: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct / toluene / 2.33 h / 100 °C / Inert atmosphere

4: trifluorormethanesulfonic acid; trifluoroacetic acid / 0.17 h

5: triethylamine / dichloromethane / 0.22 h / 0 °C

6: ammonium hydroxide / ethanol; water / 115 °C

With ammonium hydroxide; trifluorormethanesulfonic acid; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; triethylamine; trifluoroacetic acid; ruphos; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 1450621-78-9
(3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione

: 1450621-11-0
3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 65 °C

2: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

3: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 12 h / 80 °C

4: carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate / dichloromethane / 0.5 h / 20 °C

5: triethylamine / dichloromethane / 0.22 h / 0 °C

6: ammonium hydroxide / ethanol; water / 115 °C

With ammonium hydroxide; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; potassium tert-butylate; potassium carbonate; triethylamine; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;