ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate

Base Information

• Chemical Name: ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate
• CAS No.: 1450621-77-8
• Molecular Formula: C₂₁H₂₈N₂O₅
• Molecular Weight: 388.464

Synonyms:ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate

Chemical Property of ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate

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Technology Process of ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate

There total 1 articles about ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(benzylamino)acetate (6436-90-4) + (S)-2-(tert-butoxycarbonylamino)pent-4-ynoic acid (61172-66-5,63039-46-3,63039-48-5,143979-37-7) → ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate (1450621-77-8)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

Reference yield:

ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate (1450621-77-8) → (3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione (1450621-78-9)

Guidance literature:

ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With ammonia; In methanol; at 20 ℃; for 0.166667h;

Reference yield:

ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate (1450621-77-8) → C16H20N2O3

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jm5000497

upstream raw materials:

ethyl 2-(benzylamino)acetate

(S)-2-(tert-butoxycarbonylamino)pent-4-ynoic acid

Downstream raw materials:

2-(4-((2S)-4-((6-chloro-3-pyridazinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

2-(4-((2S)-4-((6-amino-3-pyridazinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

2-(4-((2S)-4-((6-amino-5-bromo-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol

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