N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-2-methyl-propanamide

Base Information

Chemical Name:N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-2-methyl-propanamide
CAS No.:1394908-06-5
Molecular Formula:C₂₄H₃₃N₃O₂
Molecular Weight:395.545
Hs Code.:

Synonyms:N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-2-methyl-propanamide

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Chemical Property of N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-2-methyl-propanamide

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Technology Process of N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-2-methyl-propanamide

There total 5 articles about N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-2-methyl-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1394909-44-4
5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine

: 79-30-1
isobutyryl chloride

: 1394908-06-5
N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-2-methyl-propanamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1394909-43-3
5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzonitrile

: 1394908-06-5
N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-2-methyl-propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; ammonia / Raney nickel / methanol / 14 °C

2: triethylamine / dichloromethane / 1 h / 20 °C

With ammonia; hydrogen; triethylamine; Raney nickel; In methanol; dichloromethane;

Reference yield:

: 325142-95-8
2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1394908-06-5
N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-2-methyl-propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

2: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1.5 h / 120 °C / Inert atmosphere; Sealed tube

3: hydrogen; ammonia / Raney nickel / methanol / 14 °C

4: triethylamine / dichloromethane / 1 h / 20 °C

With ammonia; hydrogen; sodium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; toluene;