5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine

Base Information

Chemical Name:5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine
CAS No.:1394909-44-4
Molecular Formula:C₂₀H₂₇N₃O
Molecular Weight:325.454
Hs Code.:

Synonyms:5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine

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Chemical Property of 5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine

Chemical Property:

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Technology Process of 5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine

There total 4 articles about 5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394909-43-3
5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzonitrile

: 1394909-44-4
5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine

Guidance literature:: With ammonia; hydrogen; Raney nickel; In methanol; at 14 ℃;

Reference yield:

: 57381-37-0
2-bromo-5-chloro-benzonitrile

: 1394909-44-4
5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

2: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1.5 h / 120 °C / Inert atmosphere; Sealed tube

3: hydrogen; ammonia / Raney nickel / methanol / 14 °C

With ammonia; hydrogen; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; water; toluene;

Reference yield:

: 1394909-42-2
5-chloro-2-(2,6-dimethyl-4-pyridinyl)-benzonitrile

: 1394909-44-4
5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1.5 h / 120 °C / Inert atmosphere; Sealed tube

2: hydrogen; ammonia / Raney nickel / methanol / 14 °C

With ammonia; hydrogen; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; toluene;