(2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-7-yl)methanol

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Chemical Name:(2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-7-yl)methanol
CAS No.:1365990-85-7
Molecular Formula:C₁₈H₁₃ClFN₅OS
Molecular Weight:401.852
Hs Code.:

Synonyms:(2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-7-yl)methanol

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Chemical Property of (2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-7-yl)methanol

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Technology Process of (2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-7-yl)methanol

There total 10 articles about (2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-7-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365993-05-0
2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridine-7-carbaldehyde

: 1365990-85-7
(2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-7-yl)methanol

Guidance literature:: 2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridine-7-carbaldehyde; With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

Reference yield:

: 79455-63-3
2-chloro-6-fluorobenzoyl chloride

: 1365990-85-7
(2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-7-yl)methanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 0 - 20 °C

1.3: 16 h / 20 °C

2.1: thionyl chloride / 1,2-dichloro-ethane / 116 h / Reflux; Inert atmosphere

3.1: thiourea; pyridine / isopropyl alcohol / 17 h / Reflux

3.2: 1 h / Reflux

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C / Inert atmosphere

5.1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 3 h / 70 °C

6.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4.5 h / 75 °C / Inert atmosphere

7.1: N,N,N,N,-tetramethylethylenediamine / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

8.1: water; formic acid; nickel/aluminium alloy / 4 h / 100 °C

9.1: sodium tetrahydroborate / methanol / 0 - 20 °C

9.2: 1 h / 20 °C

With pyridine; sodium tetrahydroborate; formic acid; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; nickel/aluminium alloy; water; sodium hydride; caesium carbonate; thiourea; 3-chloro-benzenecarboperoxoic acid; phosphorus(V) oxybromide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1365990-82-4
7-bromo-2-(2-chloro-6-fluorophenyl)-N-(6-methylpyrimidin-4-yl)thiazolo[5,4-c]pyridin-4-amine

: 1365990-85-7
(2-(2-chloro-6-fluorophenyl)-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-7-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N,N,-tetramethylethylenediamine / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

2.1: water; formic acid; nickel-aluminum alloy / 4 h / 100 °C

3.1: sodium tetrahydroborate / methanol / 0 - 20 °C

3.2: 1 h / 20 °C

With sodium tetrahydroborate; formic acid; N,N,N,N,-tetramethylethylenediamine; nickel-aluminum alloy; water; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; N,N-dimethyl-formamide;