methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylate

Base Information

• Chemical Name: methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylate
• CAS No.: 473911-88-5
• Molecular Formula: C₂₇H₂₈N₂O₃
• Molecular Weight: 428.531

Synonyms:methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylate

Chemical Property of methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylate

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Technology Process of methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylate

There total 1 articles about methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylic acid methyl ester (473264-25-4) + 4-cyclohexyl-benzoyl chloride (121193-16-6) → methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylate (473911-88-5)

Guidance literature:

With triethylamine; In 1,2-dichloro-ethane; Petroleum ether;

Reference yield:

methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylate (473911-88-5) → 10-(4-Cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylic acid sodium salt (473911-25-0)

Guidance literature:

With sodium hydroxide; In ethanol;

Reference yield:

1-methyl-piperazine (109-01-3) + methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylate (473911-88-5) + trichloromethyl chloroformate (503-38-8) → Methyl 10-(4-cyclohexylbenzoyl)-3-[(4-methyl-1-piperazinyl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-8-carboxylate hydrochloride salt (473911-24-9)

Guidance literature:

With hydrogenchloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate;

upstream raw materials:

10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylic acid methyl ester

4-cyclohexyl-benzoyl chloride

Downstream raw materials:

Methyl 10-(4-cyclohexylbenzoyl)-3-[(4-methyl-1-piperazinyl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-8-carboxylate hydrochloride salt

10-(4-Cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo [2,1-c][1,4] benzodiazepine-8-carboxylic acid sodium salt

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