1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil

Base Information

Chemical Name:1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil
CAS No.:178688-01-2
Molecular Formula:C₂₈H₂₇FN₂O₇Si
Molecular Weight:550.615
Hs Code.:

Synonyms:1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil

Suppliers and Price of 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil

There total 14 articles about 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 171721-06-5
1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-iodouracil

: 1066-54-2
trimethylsilylacetylene

: 178688-01-2
1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 50 - 60 ℃; for 4.5h;
DOI:10.1021/jm960098l

Reference yield:

: 3080-30-6,6974-32-9,14215-97-5,16162-35-9,20822-87-1,21138-42-1,22249-15-6,22249-17-8,26287-72-9,53403-35-3,53403-36-4,57236-69-8,70832-64-3,99395-04-7,100101-51-7,109668-83-9,120019-54-7
1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose

: 178688-01-2
1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) HCl(g), AcCl, 2.) H₂O / 1.) CH₂Cl₂, 0 deg C, 2.) CH₃CN

2: 1.) SO₂Cl₂ / 1.) CH₂Cl₂, DMF, from -40 deg C to RT, 3.5 h, 2.) CH₂Cl₂, DMF, RT, 15 h

3: 65 percent / KHF₂, 48percent aq. HF / various solvent(s) / 1 h / 160 °C

4: 100 percent / HBr, AcOH / CH₂Cl₂ / 20 h / Ambient temperature

5: 1.) HMDS, (NH₄)2SO₄ / 2.) dichloroethane, reflux, 36 h

6: 73 percent / Et₃N, (Ph₃P)2PdCl₂, CuI / 4.5 h / 50 - 60 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; ammonium sulfate; copper(l) iodide; sulfuryl dichloride; potassium hydrogen bifluoride; hydrogen fluoride; water; hydrogen bromide; acetic acid; triethylamine; acetyl chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;
DOI:10.1021/jm960098l

Reference yield:

: 98-88-4
benzoyl chloride

: 178688-01-2
1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-[2-(trimethylsilyl)acetylenyl]uracil

Guidance literature:: Multi-step reaction with 10 steps

1: 98 percent / pyridine / 3 h / Ambient temperature

2: 1percent HCl / methanol / 30 h / Ambient temperature

3: pyridine / 3 h / Ambient temperature

4: AcOH, conc. H₂SO₄ / Ambient temperature

5: 1.) HCl(g), AcCl, 2.) H₂O / 1.) CH₂Cl₂, 0 deg C, 2.) CH₃CN

6: 1.) SO₂Cl₂ / 1.) CH₂Cl₂, DMF, from -40 deg C to RT, 3.5 h, 2.) CH₂Cl₂, DMF, RT, 15 h

7: 65 percent / KHF₂, 48percent aq. HF / various solvent(s) / 1 h / 160 °C

8: 100 percent / HBr, AcOH / CH₂Cl₂ / 20 h / Ambient temperature

9: 1.) HMDS, (NH₄)2SO₄ / 2.) dichloroethane, reflux, 36 h

10: 73 percent / Et₃N, (Ph₃P)2PdCl₂, CuI / 4.5 h / 50 - 60 °C

With pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; ammonium sulfate; copper(l) iodide; sulfuryl dichloride; potassium hydrogen bifluoride; sulfuric acid; hydrogen fluoride; water; hydrogen bromide; acetic acid; triethylamine; acetyl chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; dichloromethane;
DOI:10.1021/jm960098l