1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one

Base Information

Chemical Name:1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one
CAS No.:103979-79-9
Molecular Formula:C₁₇H₂₁NO₄S
Molecular Weight:335.424
Hs Code.:

Synonyms:1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one

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Chemical Property of 1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one

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Technology Process of 1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one

There total 4 articles about 1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.3%

: 103979-78-8
4-(2-Oxo-5-phenylsulfanyl-pyrrolidin-1-yl)-butyric acid ethyl ester

: 109-94-4
formic acid ethyl ester

: 103979-79-9
1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one

Guidance literature:: With sodium hydride; In benzene; 1.) 0 deg C, 2.) room temp.;

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 103979-79-9
1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium hydride / 1.) dimethylformamide, 0 deg C, 30 min, 2.) DMF, room temp.

2: 1.) sodium borohydride, 2.) hydrogen chloride / 1.) 0 deg C, 2 h, pH 8-9, 2.) pH 3, 15 min, 0 deg C

3: toluene-p-sulponic acid monohydrate / 0.25 h / Ambient temperature

4: 72.3 percent / sodium hydride / benzene / 1.) 0 deg C, 2.) room temp.

With hydrogenchloride; sodium tetrahydroborate; sodium hydride; toluene-4-sulfonic acid; In benzene;

Reference yield:

: 103979-77-7
1-(3-ethoxycarbonylpropyl)pyrrolidine-2,5-dione

: 103979-79-9
1-(3-ethoxycarbonyl-3-hydroxymethylenepropyl)-5-phenyl-thiopyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium borohydride, 2.) hydrogen chloride / 1.) 0 deg C, 2 h, pH 8-9, 2.) pH 3, 15 min, 0 deg C

2: toluene-p-sulponic acid monohydrate / 0.25 h / Ambient temperature

3: 72.3 percent / sodium hydride / benzene / 1.) 0 deg C, 2.) room temp.

With hydrogenchloride; sodium tetrahydroborate; sodium hydride; toluene-4-sulfonic acid; In benzene;