2-(4-benzyloxy-3,5-dimethylphenyl)-5,7-difluoro-3H-quinazolin-4-one

Base Information

• Chemical Name: 2-(4-benzyloxy-3,5-dimethylphenyl)-5,7-difluoro-3H-quinazolin-4-one
• CAS No.: 1253731-71-3
• Molecular Formula: C₂₃H₁₈F₂N₂O₂
• Molecular Weight: 392.405
• Mol file: 1253731-71-3.mol

Synonyms:2-(4-benzyloxy-3,5-dimethylphenyl)-5,7-difluoro-3H-quinazolin-4-one

Chemical Property of 2-(4-benzyloxy-3,5-dimethylphenyl)-5,7-difluoro-3H-quinazolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-benzyloxy-3,5-dimethylphenyl)-5,7-difluoro-3H-quinazolin-4-one

There total 4 articles about 2-(4-benzyloxy-3,5-dimethylphenyl)-5,7-difluoro-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-amino-4,6-difluoro-benzamide (893428-66-5) + 3,5-dimethyl-4-benzyloxy benzaldehyde (144896-51-5) → 2-(4-benzyloxy-3,5-dimethylphenyl)-5,7-difluoro-3H-quinazolin-4-one (1253731-71-3)

Guidance literature:

With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 115 - 120 ℃; for 16h; Product distribution / selectivity;

Reference yield:

benzyl bromide (100-39-0) → 2-(4-benzyloxy-3,5-dimethylphenyl)-5,7-difluoro-3H-quinazolin-4-one (1253731-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 110 - 120 °C

With sodium hydrogen sulfate; sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

2-amino-4,6-difluorobenzoic acid (126674-77-9) → 2-(4-benzyloxy-3,5-dimethylphenyl)-5,7-difluoro-3H-quinazolin-4-one (1253731-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 1 h / 20 °C

1.2: 6 h / 20 °C

2.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 110 - 120 °C

With sodium hydrogen sulfate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide;

upstream raw materials:

2-amino-4,6-difluoro-benzamide

3,5-dimethyl-4-benzyloxy benzaldehyde

benzyl bromide

2-amino-4,6-difluorobenzoic acid

Downstream raw materials:

2-(4-benzyloxy-3,5-dimethylphenyl)-7-fluoro-5-methoxy-3H-quinazolin-4-one

2-(4-benzyloxy-3,5-dimethylphenyl)-5-(2-dimethylaminoethoxy)-7-fluoro-3H-quinazolin-4-one

2-(4-benzyloxy-3,5-dimethylphenyl)-7-fluoro-5-(2-methoxyethoxy)-3H-quinazolin-4-one

2-(4-benzyloxy-3,5-dimethylphenyl)-7-methoxy-5-(2-methoxyethoxy)-3H-quinazolin-4-one