1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane

Base Information

Chemical Name:1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane
CAS No.:1408062-21-4
Molecular Formula:C₂₀H₂₄O₄
Molecular Weight:328.408
Hs Code.:

Synonyms:1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane

Suppliers and Price of 1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane

Chemical Property:

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Technology Process of 1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane

There total 10 articles about 1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1408062-17-8
E-1-[5-benzyloxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-benzyloxy-3-methoxyphenyl]ethene

: 1371574-56-9
E-1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethene

: 1408062-21-4
1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane

Guidance literature:: With cyclohexa-1,4-diene; palladium 10% on activated carbon; In ethanol; Reflux; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.02.017

Reference yield:

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 1371574-56-9
E-1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethene

: 1408062-21-4
1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2.33 h / 0 - 20 °C / Inert atmosphere

2: sodium hydroxide / methanol / 45 °C / Inert atmosphere

3: pyridine / 2 h / 20 °C / Darkness; Inert atmosphere

4: thionyl chloride / 4 h / 110 °C

5: palladium diacetate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; N-ethylmorpholine; / 5,5-dimethyl-1,3-cyclohexadiene / 130 °C / Inert atmosphere; Reflux

6: sodium hydroxide; water / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

7: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

8: cyclohexa-1,4-diene; palladium 10% on activated carbon / ethanol / Reflux; Inert atmosphere

With N-ethylmorpholine;; pyridine; thionyl chloride; cyclohexa-1,4-diene; palladium 10% on activated carbon; water; palladium diacetate; sodium hydride; sodium hydroxide; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; N,N-dimethyl-formamide; mineral oil; 5: |Heck Reaction;
DOI:10.1016/j.ejmech.2013.02.017

Reference yield:

: 54915-31-0
methyl 3-(benzyloxy)-5-hydroxybenzoate

: 1371574-56-9
E-1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethene

: 1408062-21-4
1-[5-hydroxy-3-(3-methylbut-2-enyloxy)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethane

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / methanol / 45 °C / Inert atmosphere

2: pyridine / 2 h / 20 °C / Darkness; Inert atmosphere

3: thionyl chloride / 4 h / 110 °C

4: palladium diacetate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; N-ethylmorpholine; / 5,5-dimethyl-1,3-cyclohexadiene / 130 °C / Inert atmosphere; Reflux

5: sodium hydroxide; water / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

6: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

7: cyclohexa-1,4-diene; palladium 10% on activated carbon / ethanol / Reflux; Inert atmosphere

With N-ethylmorpholine;; pyridine; thionyl chloride; cyclohexa-1,4-diene; palladium 10% on activated carbon; water; palladium diacetate; sodium hydride; sodium hydroxide; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; N,N-dimethyl-formamide; mineral oil; 4: |Heck Reaction;
DOI:10.1016/j.ejmech.2013.02.017