ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate

Base Information

• Chemical Name: ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate
• CAS No.: 190954-59-7
• Molecular Formula: C₁₈H₂₃NO₃
• Molecular Weight: 301.386

Synonyms:ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate

Chemical Property of ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate

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Technology Process of ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate

There total 8 articles about ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

ethyl 1-{5-oxo-1-[(S)-1-phenylethyl]-2,5-dihydro-1H-pyrrol-3-yl}cyclopropanecarboxylate (181941-63-9) → ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate (190954-59-7) + ethyl 1-{(3R)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate (431058-48-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; at 20 ℃; for 18h;

DOI:10.1021/jm020328y

Reference yield: 74.0%

ethyl 1-{5-oxo-1-[(S)-1-phenylethyl]-2,5-dihydro-1H-pyrrol-3-yl}cyclopropanecarboxylate (181941-63-9) → ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate (190954-59-7)

Guidance literature:

With platinum on carbon; hydrogen; In ethyl acetate; at 20 ℃; for 17h;

DOI:10.1016/j.bmc.2009.08.026

Reference yield:

ethyl 1-{5-oxo-1-[(S)-1-phenylethyl]-2,5-dihydro-1H-pyrrol-3-yl}cyclopropanecarboxylate (181941-63-9) → ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate (190954-59-7)

Guidance literature:

With hydrogen; platinum; In ethyl acetate;

upstream raw materials:

ethyl 1-{5-oxo-1-[(S)-1-phenylethyl]-2,5-dihydro-1H-pyrrol-3-yl}cyclopropanecarboxylate

(S)-1-phenyl-ethylamine

ethyl (E)-3-(1-ethoxycarbonylcyclopropan-1-yl)-2-butenoate

ethyl 3-(1-ethoxycarbonylcyclopropan-1-yl)-3-hydroxybutanoate

Downstream raw materials:

ethyl 1-{(3S)-1-[(S)-1-phenylethyl]-5-thioxopyrrolidin-3-yl}cyclopropanecarboxylate

ethyl 1-{(3S,4R)-4-fluoro-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate

ethyl 1-{(3S)-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate

ethyl 1-{(3S,4SR)-4-fluoro-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate

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