2-[(2Z)-5-(2-bromo-5-methoxy-phenyl)-pent-2-enyl]-1,3-dimethyloctahydrobenzo[1,3,2]diazaphosphole 2-oxide

Base Information

• Chemical Name: 2-[(2Z)-5-(2-bromo-5-methoxy-phenyl)-pent-2-enyl]-1,3-dimethyloctahydrobenzo[1,3,2]diazaphosphole 2-oxide
• CAS No.: 1207541-76-1
• Molecular Formula: C₂₀H₃₀BrN₂O₂P
• Molecular Weight: 441.348
• Mol file: 1207541-76-1.mol

Synonyms:2-[(2Z)-5-(2-bromo-5-methoxy-phenyl)-pent-2-enyl]-1,3-dimethyloctahydrobenzo[1,3,2]diazaphosphole 2-oxide

Chemical Property of 2-[(2Z)-5-(2-bromo-5-methoxy-phenyl)-pent-2-enyl]-1,3-dimethyloctahydrobenzo[1,3,2]diazaphosphole 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2Z)-5-(2-bromo-5-methoxy-phenyl)-pent-2-enyl]-1,3-dimethyloctahydrobenzo[1,3,2]diazaphosphole 2-oxide

There total 1 articles about 2-[(2Z)-5-(2-bromo-5-methoxy-phenyl)-pent-2-enyl]-1,3-dimethyloctahydrobenzo[1,3,2]diazaphosphole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(Z)-1-bromo-2-(5-chloropent-3-enyl)-4-methoxybenzene (1207541-68-1) + (3aR,7aR)-2-Ethoxy-1,3-dimethyl-octahydro-benzo[1,3,2]diazaphosphole → 2-[(2Z)-5-(2-bromo-5-methoxy-phenyl)-pent-2-enyl]-1,3-dimethyloctahydrobenzo[1,3,2]diazaphosphole 2-oxide (1207541-76-1)

Guidance literature:

With sodium iodide; In toluene; at 110 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol902638w

Reference yield: 59.0%

2-methyl-2-cyclopenten-1-one (1120-73-6) + 2-[(2Z)-5-(2-bromo-5-methoxy-phenyl)-pent-2-enyl]-1,3-dimethyloctahydrobenzo[1,3,2]diazaphosphole 2-oxide (1207541-76-1) + allyl bromide (106-95-6) → C26H38BrN2O3P + 2-{(3S,1E)-3-[(1S,2S)-2-allyl-2-methyl-3-oxocyclopentyl]-5-(2-bromo-5-methoxyphenyl)pent-1-enyl}-(3aR,7aR)-1,3-dimethyl-octahydrobenzo[1,3,2]diazaphosphole 2-oxide (1207541-77-2) + C32H46BrN2O3P

Guidance literature:

2-[(2Z)-5-(2-bromo-5-methoxy-phenyl)-pent-2-enyl]-1,3-dimethyloctahydrobenzo[1,3,2]diazaphosphole 2-oxide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

2-methyl-2-cyclopenten-1-one; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; hexane; at 0 - 20 ℃; optical yield given as %de; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol902638w

upstream raw materials:

(Z)-1-bromo-2-(5-chloropent-3-enyl)-4-methoxybenzene

Downstream raw materials:

2-{(3S,1E)-3-[(1S,2S)-2-allyl-2-methyl-3-oxocyclopentyl]-5-(2-bromo-5-methoxyphenyl)pent-1-enyl}-(3aR,7aR)-1,3-dimethyl-octahydrobenzo[1,3,2]diazaphosphole 2-oxide