(Z)-tert-butyldimethyl{[4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-1-en-3-yn-1-yl]oxy}silane

Base Information

Chemical Name:(Z)-tert-butyldimethyl{[4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-1-en-3-yn-1-yl]oxy}silane
CAS No.:1366416-91-2
Molecular Formula:C₂₄H₂₇F₃OSi
Molecular Weight:416.558
Hs Code.:

Synonyms:(Z)-tert-butyldimethyl{[4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-1-en-3-yn-1-yl]oxy}silane

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Chemical Property of (Z)-tert-butyldimethyl{[4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-1-en-3-yn-1-yl]oxy}silane

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Technology Process of (Z)-tert-butyldimethyl{[4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-1-en-3-yn-1-yl]oxy}silane

There total 5 articles about (Z)-tert-butyldimethyl{[4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-1-en-3-yn-1-yl]oxy}silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: C₁₈H₁₃F₃O

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1366416-91-2
(Z)-tert-butyldimethyl{[4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-1-en-3-yn-1-yl]oxy}silane

Guidance literature:: C₁₈H₁₃F₃O; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.333333h;

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃; for 0.166667h;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 12h; optical yield given as %de;
DOI:10.1039/c1ob06693e

Reference yield:

: 1366416-76-3
4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-3-yn-1-ol

: 1366416-91-2
(Z)-tert-butyldimethyl{[4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-1-en-3-yn-1-yl]oxy}silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: Jones reagent / acetone / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C

2.2: 0.17 h / -78 °C

2.3: 12 h / -78 - 20 °C

With Jones reagent; lithium diisopropyl amide; In tetrahydrofuran; acetone;
DOI:10.1039/c1ob06693e

Reference yield:

: 16017-24-6
3-p-tolylprop-2-yn-1-ol

: 1366416-91-2
(Z)-tert-butyldimethyl{[4-(4-methylphenyl)-1-[4-(trifluoromethyl)phenyl]but-1-en-3-yn-1-yl]oxy}silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: mercury dichloride; zinc / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

3.1: Jones reagent / acetone / 0 - 20 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C

4.2: 0.17 h / -78 °C

4.3: 12 h / -78 - 20 °C

With Jones reagent; carbon tetrabromide; triphenylphosphine; mercury dichloride; zinc; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1039/c1ob06693e