1-Bromo-2,4-dimethoxybenzene

Base Information

• Chemical Name: 1-Bromo-2,4-dimethoxybenzene
• CAS No.: 17715-69-4
• Molecular Formula: C8H9BrO2
• Molecular Weight: 217.062
• Hs Code.: 29093090
• European Community (EC) Number: 241-717-0
• UNII: QU54UE5GSE
• DSSTox Substance ID: DTXSID50170262
• Nikkaji Number: J236.216C
• Wikidata: Q72454778
• Mol file: 17715-69-4.mol

Synonyms:1-Bromo-2,4-dimethoxybenzene;17715-69-4;2,4-Dimethoxybromobenzene;Benzene, 1-bromo-2,4-dimethoxy-;1,3-Dimethoxy-4-bromobenzene;2,4-dimethoxy-1-bromobenzene;4-Bromo-1,3-dimethoxybenzene;MFCD00009844;QU54UE5GSE;2,4-dimethoxy bromobenzene;2,4-Dimethoxyphenyl bromide;1-Bromo-2,4-dimethoxy-benzene;EINECS 241-717-0;4-bromo-3-methoxyanisole;4-Bromoresorcinol dimethyl ether;UNII-QU54UE5GSE;bromo-2,4-dimethoxybenzene;SCHEMBL167090;1 -Bromo-2,4-dimethoxybenzene;NIUZVSQOXJIHBL-UHFFFAOYSA-;DTXSID50170262;1-Bromo-2,4-dimethoxybenzene, 97%;AKOS000171127;AM62550;FS-1520;AC-27903;SY014971;B1481;CS-0008438;FT-0607443;EN300-65431;F21465;J-640218;J-800219;W-206242;F0001-0643;Z299596224

Chemical Property of 1-Bromo-2,4-dimethoxybenzene

Chemical Property:

• Appearance/Colour: clear slightly yellow liquid
• Vapor Pressure: 0.00598mmHg at 25°C
• Melting Point: 25-26 °C(lit.)
• Refractive Index: n20/D 1.572(lit.)
• Boiling Point: 281.7 °C at 760 mmHg
• Flash Point: 110.5 °C
• PSA: 18.46000
• Density: 1.412 g/cm³
• LogP: 2.46630
• Storage Temp.: 0-6°C
• Water Solubility.: insoluble
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 215.97859
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-2,4-dimethoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)Br)OC
• Uses: 1-Bromo-2,4-dimethoxybenzene was used in the synthesis of 2,3-disubstituted benzo[b]furans. It was also used in the synthesis of dendrimer Si[CH2CH2Si(Me)2-2,4-(MeO)2-C6H3]4.

Technology Process of 1-Bromo-2,4-dimethoxybenzene

There total 23 articles about 1-Bromo-2,4-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,3-Dimethoxybenzene (151-10-0) → 1-Bromo-2,4-dimethoxybenzene (17715-69-4)

Guidance literature:

With benzyltriphenylphosphonium peroxodisulfate; potassium bromide; In acetonitrile; for 4.5h; Heating;

DOI:10.1080/00397910601033906

Reference yield: 98.0%

4-Bromoresorcinol (6626-15-9) + methyl iodide (74-88-4) → 1-Bromo-2,4-dimethoxybenzene (17715-69-4)

Guidance literature:

With potassium carbonate; In acetone; for 20h; Reflux;

Reference yield: 94.0%

2,4 dimethoxybenzoic acid (91-52-1) → 1-Bromo-2,4-dimethoxybenzene (17715-69-4)

Guidance literature:

With potassium phosphate; tetrabuthylammonium tribromide; In acetonitrile; at 20 ℃; for 16h;

DOI:10.1039/c8sc01016a

upstream raw materials:

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione

1,3-Dimethoxybenzene

4,6-dibromo-1,3-dimethoxybenzene

4-Bromoresorcinol

Downstream raw materials:

2-(5-bromo-2,4-dimethoxy-benzoyl)-benzoic acid

2,4-dimethoxytoluene

4,6-dibromo-1,3-dimethoxybenzene

2-bromo-5-methoxycyclohexa-2,5-diene-1,4-dione

Refernces

• 1、 Moad et al.. "". . p. 6068,6072, 6075. Retrieved 1979.
• 2、 Strehl, Julia,Abraham, Marvin L.,Hilt, Gerhard. "Linear Paired Electrolysis—Realising 200 % Current Efficiency for Stoichiometric Transformations—The Electrochemical Bromination of Alkenes". supporting information. p. 9996 - 10000. Retrieved 2021/03/31.
• 3、 Richards, Kenza,Petit, Eddy,Legrand, Yves-Marie,Grison, Claude. "Eco-Friendly Methodology for the Formation of Aromatic Carbon–Heteroatom Bonds by Using Green Ionic Liquids". supporting information. p. 809 - 814. Retrieved 2020/11/30.