benzyl (2S)-2-[(1'E)-2'-nitroprop-1'-en-1'-yl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:benzyl (2S)-2-[(1'E)-2'-nitroprop-1'-en-1'-yl]pyrrolidine-1-carboxylate
CAS No.:1350627-29-0
Molecular Formula:C₁₅H₁₈N₂O₄
Molecular Weight:290.319
Hs Code.:

Synonyms:benzyl (2S)-2-[(1'E)-2'-nitroprop-1'-en-1'-yl]pyrrolidine-1-carboxylate

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Chemical Property of benzyl (2S)-2-[(1'E)-2'-nitroprop-1'-en-1'-yl]pyrrolidine-1-carboxylate

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Technology Process of benzyl (2S)-2-[(1'E)-2'-nitroprop-1'-en-1'-yl]pyrrolidine-1-carboxylate

There total 5 articles about benzyl (2S)-2-[(1'E)-2'-nitroprop-1'-en-1'-yl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: C₁₅H₂₀N₂O₅

: 1350627-29-0
benzyl (2S)-2-[(1'E)-2'-nitroprop-1'-en-1'-yl]pyrrolidine-1-carboxylate

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.666667h;
DOI:10.1016/j.tet.2013.05.055

Reference yield:

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 1350627-29-0
benzyl (2S)-2-[(1'E)-2'-nitroprop-1'-en-1'-yl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 6 h / 0 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

2.2: -78 °C

3.1: potassium hydroxide / methanol; water / 0.17 h

3.2: 1 h / 20 °C

4.1: methanesulfonyl chloride / dichloromethane / 0.33 h / 0 °C

4.2: 0.33 h / 0 °C

With oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; methanesulfonyl chloride; potassium hydroxide; In methanol; dichloromethane; water; acetonitrile; 2.1: Swern oxidation / 2.2: Swern oxidation / 3.1: Henry reaction / 3.2: Henry reaction;
DOI:10.1016/j.tetlet.2011.09.118

Reference yield:

: 6216-63-3
N-Cbz-Prolinol

: 1350627-29-0
benzyl (2S)-2-[(1'E)-2'-nitroprop-1'-en-1'-yl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

1.2: -78 °C

2.1: potassium hydroxide / methanol; water / 0.17 h

2.2: 1 h / 20 °C

3.1: methanesulfonyl chloride / dichloromethane / 0.33 h / 0 °C

3.2: 0.33 h / 0 °C

With oxalyl dichloride; dimethyl sulfoxide; methanesulfonyl chloride; potassium hydroxide; In methanol; dichloromethane; water; 1.1: Swern oxidation / 1.2: Swern oxidation / 2.1: Henry reaction / 2.2: Henry reaction;
DOI:10.1016/j.tetlet.2011.09.118