4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester

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Chemical Name:4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester
CAS No.:256410-31-8
Molecular Formula:C₄₀H₃₆N₂O₆
Molecular Weight:640.736
Hs Code.:

Synonyms:4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester

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Chemical Property of 4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester

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Technology Process of 4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester

There total 8 articles about 4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52289-93-7
o-Methoxybenzyl bromide

: 256410-31-8
4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran; hexane / -55 - -25 °C

1.2: 95 percent / tetrahydrofuran; hexane / 1.5 h / -25 - 0 °C

2.1: dimethylformamide; acetic acid

3.1: tetrabutylammonium fluoride / tetrahydrofuran / 25 °C

4.1: aq. NaOH / acetone

5.1: Et₃N; DMAP / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; tetrabutyl ammonium fluoride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0968-0896(01)00209-7

Reference yield:

: 33375-06-3
(1R)-1-phenylethyl isocyanate

: 402563-68-2
(3S,4S)-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-3-(2-methoxybenzyl)azetidin-2-one

: 256410-31-8
4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/S0968-0896(01)00209-7

Reference yield:

: 908093-98-1
diazodiphenylmethane

: 256410-31-8
4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / CH₂Cl₂; methanol / 16 h / 20 °C

2: aq. NaOH / acetone

3: Et₃N; DMAP / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; triethylamine; In methanol; dichloromethane; acetone;
DOI:10.1016/S0968-0896(01)00209-7