52289-93-7

Basic information

• Product Name: 1-(bromomethyl)-2-methoxybenzene
• Synonyms: 1-(bromomethyl)-2-me;2-(Bromomethyl)anisole;2-Methoxy-1-(bromomethyl)benzene;alpha-Bromo-2-methoxytoluene;MonoMethoxybenzyl broMide;1-(bromomethyl)-2-methoxybenzene;o-Methoxybenzylbromide;2-Methoxy benzyl bromide
• CAS NO: 52289-93-7
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 201.06000
• Mol File: 52289-93-7.mol
• Article Data: 42

Chemical Properties

• Melting Point: 47-50℃
• Boiling Point: 228℃
• Flash Point: 90℃
• Appearance: /
• Density: 1.406
• Vapor Pressure: 0.111mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 1-(bromomethyl)-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(bromomethyl)-2-methoxybenzene(52289-93-7)
• EPA Substance Registry System: 1-(bromomethyl)-2-methoxybenzene(52289-93-7)

Safety Data

• Hazardous Substances Data: 52289-93-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9BrO/c1-10-8-5-3-2-4-7(8)6-9/h2-5H,6H2,1H3

Upstream product

• 100-66-3 methoxybenzene 
• 74-95-3 1,1-dibromomethane 
• 612-16-8 (2-methoxyphenyl)methanol 
• 497-19-8 sodium carbonate 
• 90-02-8 salicylaldehyde 
• 135-02-4 ortho-anisaldehyde 
• 578-58-5 2-methylmethoxybenzene 

Downstream Products

• 148451-86-9 (S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester 
• 757188-19-5 trans-1-methoxy-2-(3-methyl-octa-2,7-dienyl)-benzene 
• 202822-66-0 3-[(2-methoxyphenyl)-methyl]-5-[4-(trifluoromethyl)phenyl]1,3,4-oxadiazol-2-(3H)-one 

Relevant articles and documents

Photocatalytic continuous bromination method

The invention provides a photocatalytic continuous bromination method. The method comprises the following steps: carrying out a first-stage photocatalytic continuous bromination reaction on a materialcontaining an aromatic substrate with a structural general formula I and a bromination reagent in a first continuous illumination reactor to form a first continuous system; overflowing the obtained first continuous system into a second continuous illumination reactor for a second-stage photocatalytic continuous bromination reaction to form a second continuous system; and purifying the second continuous system, wherein the structural general formula I is shown in the specification, R is selected from any one of carboxyl, ester group, NO2, CN, C1 to C8 alkyl and alkoxy, and R1 is C1 to C8 alkyl; n is 1 or 2; X is N or C, and the bromination reagent is Nbromo succinimide or dibromohydantoin. According to the bromination reagent, the selectivity of a product is improved, so the yield of the product is improved; the photocatalytic continuous bromination reaction of the two stages effectively relieves the reaction heat accumulation, and enhances the yield of the target product.

Photochemical benzylic bromination in continuous flow using BrCCl3 and its application to telescoped p-methoxybenzyl protection

BrCCl3 represents a rarely used benzylic brominating reagent with complementary reactivity to other reagents. Its reactivity has been revisited in continuous flow, revealing compatibility with electron-rich aromatic substrates. This has brought about the development of a p-methoxybenzyl bromide generator for PMB protection, which was successfully demonstrated on a pharmaceutically relevant intermediate on 11 g scale, giving 91% yield and a PMB-Br space-time-yield of 1.27 kg L?1 h?1

PYRIMIDINE COMPOUNDS CONTAINING ACIDIC GROUPS

The present disclosure relates to a class of pyrimidine derivatives having immunomodulating properties that act via TLR7 which are useful in the treatment of viral infections and cancers.