diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate

Base Information

Chemical Name:diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate
CAS No.:1394290-13-1
Molecular Formula:C₆₆H₇₄N₄O₈
Molecular Weight:1051.34
Hs Code.:

diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate

Synonyms:diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate

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Chemical Property of diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate

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Technology Process of diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate

There total 5 articles about diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1394290-12-0
ethyl 3-[acetoxy(4-tert-butylphenyl)methyl]-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

: 332140-32-6
diethyl 4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,7-dicarboxylate

: 1394290-13-1
diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate

Guidance literature:: With toluene-4-sulfonic acid; In acetic acid; at 20 ℃; for 3h; Darkness;
DOI:10.1039/c2ob25930c

Reference yield:

: 1394290-10-8
ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

: 1394290-13-1
diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol; tetrahydrofuran / 2 h / 20 °C / Cooling with ice; Inert atmosphere

2: dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid; acetic acid / 3 h / 20 °C / Inert atmosphere; Darkness

With dmap; sodium tetrahydroborate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1394290-11-9
ethyl 3-[(4-tert-butylphenyl)hydroxymethyl]-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

: 1394290-13-1
diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid; acetic acid / 3 h / 20 °C / Inert atmosphere; Darkness

With dmap; toluene-4-sulfonic acid; acetic acid; In dichloromethane;