ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

Base Information

Chemical Name:ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate
CAS No.:1394290-10-8
Molecular Formula:C₂₄H₂₇NO₃
Molecular Weight:377.483
Hs Code.:

Synonyms:ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

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Chemical Property of ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

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Technology Process of ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

There total 1 articles about ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

: 200353-88-4
ethyl 4,7-dihydro-4β,7β-ethano-2H-isoindole-1-carboxylate

: 1394290-10-8
ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

Guidance literature:: 4-(1,1-dimethylethyl)benzoic acid; With trifluoroacetic anhydride; at 20 ℃; for 0.25h; Inert atmosphere;

ethyl 4,7-dihydro-4β,7β-ethano-2H-isoindole-1-carboxylate; With trifluoroacetic acid; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1039/c2ob25930c

Reference yield: 95.0%

: 1394290-10-8
ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

: 1394290-11-9
ethyl 3-[(4-tert-butylphenyl)hydroxymethyl]-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c2ob25930c

Reference yield:

: 1394290-10-8
ethyl 3-(4-tert-butylbenzoyl)-4,7-dihydro-4,7-ethano-2H-isoindole-1-carboxylate

: 1394290-13-1
diethyl 3,7-bis[(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindolyl)(4-tert-butylphenyl)methyl]-4,8-dihydro-4,8-ethanopyrrolo[3,4-f]isoindole-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol; tetrahydrofuran / 2 h / 20 °C / Cooling with ice; Inert atmosphere

2: dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid; acetic acid / 3 h / 20 °C / Inert atmosphere; Darkness

With dmap; sodium tetrahydroborate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; dichloromethane;