5-[5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridin-2-yl]-N-methyl-1,2,4-oxadiazole-3-carboxamide

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Chemical Name:5-[5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridin-2-yl]-N-methyl-1,2,4-oxadiazole-3-carboxamide
CAS No.:1310805-84-5
Molecular Formula:C₂₅H₂₅N₇O₆
Molecular Weight:519.517
Hs Code.:

Synonyms:5-[5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridin-2-yl]-N-methyl-1,2,4-oxadiazole-3-carboxamide

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Chemical Property of 5-[5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridin-2-yl]-N-methyl-1,2,4-oxadiazole-3-carboxamide

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Technology Process of 5-[5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridin-2-yl]-N-methyl-1,2,4-oxadiazole-3-carboxamide

There total 9 articles about 5-[5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridin-2-yl]-N-methyl-1,2,4-oxadiazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310809-58-5
C₂₆H₂₆N₆O₇

: 1310805-84-5
5-[5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridin-2-yl]-N-methyl-1,2,4-oxadiazole-3-carboxamide

Guidance literature:: With methylamine; In tetrahydrofuran; ethanol; water; for 1.5h;

Reference yield:

: 35120-18-4
ethyl 1-bromocyclobutane-1-carboxylate

: 1310805-84-5
5-[5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridin-2-yl]-N-methyl-1,2,4-oxadiazole-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 35 h / 80 - 120 °C

2.1: sodium hydroxide / ethanol; water / 4 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 50 °C

3.2: 0.5 h / Cooling with ice

4.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3000.3 Torr

6.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 - 120 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

8.1: sodium hydroxide; water / ethanol / 3 h / 20 °C

9.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1-methyl-pyrrolidin-2-one / 6 h / 20 - 100 °C

10.1: methylamine / ethanol; water; tetrahydrofuran / 1.5 h

With 1H-imidazole; 1-hydroxy-7-aza-benzotriazole; tetrabutyl ammonium fluoride; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; methylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 915771-04-9
3-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)-5-[(phenylmethyl)oxy]benzamide

: 1310805-84-5
5-[5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridin-2-yl]-N-methyl-1,2,4-oxadiazole-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 35 h / 80 - 120 °C

2.1: sodium hydroxide / ethanol; water / 4 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 50 °C

3.2: 0.5 h / Cooling with ice

4.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3000.3 Torr

6.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 - 120 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

8.1: sodium hydroxide; water / ethanol / 3 h / 20 °C

9.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1-methyl-pyrrolidin-2-one / 6 h / 20 - 100 °C

10.1: methylamine / ethanol; water; tetrahydrofuran / 1.5 h

With 1H-imidazole; 1-hydroxy-7-aza-benzotriazole; tetrabutyl ammonium fluoride; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; methylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;