Acetic acid 6-({[4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

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Chemical Name:Acetic acid 6-({[4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester
CAS No.:173952-03-9
Molecular Formula:C₂₉H₂₅N₅O₆
Molecular Weight:539.547
Hs Code.:

Synonyms:Acetic acid 6-({[4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

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Chemical Property of Acetic acid 6-({[4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

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Technology Process of Acetic acid 6-({[4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

There total 7 articles about Acetic acid 6-({[4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 112889-01-7
Acetic acid 6-bromomethyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

: 173952-00-6
N-(3-Nitro-benzyl)-4-prop-2-ynylamino-benzamide

: 173952-03-9
Acetic acid 6-({[4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

Guidance literature:: With calcium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;
DOI:10.1021/jm950645n

Reference yield:

: 2941-78-8
2-Amino-5-methylbenzoic acid

: 173952-03-9
Acetic acid 6-({[4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / sodium methoxide / methanol / a) 30 min, b) 80 deg C, 2 h

2: 89 percent / dimethylformamide / 3 h / 80 °C

3: 64 percent / N-bromosuccinimide, benzoyl peroxide, cyclohexene oxide / CCl₄ / 2 h / Heating

4: 78 percent / CaCO₃ / dimethylformamide / 18 h / 80 °C

With N-Bromosuccinimide; Perbenzoic acid; sodium methylate; cyclohexane-1,2-epoxide; calcium carbonate; In methanol; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950645n

Reference yield:

: 7409-18-9
3-nitrobenzylamine

: 173952-03-9
Acetic acid 6-({[4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphorazidate, triethylamine / dimethylformamide / 16 h

2: 78 percent / CaCO₃ / dimethylformamide / 18 h / 80 °C

With diphenyl phosphoryl azide; triethylamine; calcium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm950645n