tert-butyl 4-(4-(3-(methoxycarbonyl)-4-methylphenyl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(3-(methoxycarbonyl)-4-methylphenyl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate
CAS No.:1415312-41-2
Molecular Formula:C₂₁H₂₈N₄O₄
Molecular Weight:400.478
Hs Code.:

Synonyms:tert-butyl 4-(4-(3-(methoxycarbonyl)-4-methylphenyl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(3-(methoxycarbonyl)-4-methylphenyl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(3-(methoxycarbonyl)-4-methylphenyl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(4-(3-(methoxycarbonyl)-4-methylphenyl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.5%

: 1415312-25-2
tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate

: 79669-50-4
methyl 2-methyl-5-bromobenzoate

: 1415312-41-2
tert-butyl 4-(4-(3-(methoxycarbonyl)-4-methylphenyl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; cesium fluoride; In methanol; at 140 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.tetlet.2012.10.034

Reference yield:

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 1415312-41-2
tert-butyl 4-(4-(3-(methoxycarbonyl)-4-methylphenyl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1.25 h / 20 °C / Inert atmosphere

1.2: 20 h / 60 °C / Inert atmosphere

2.1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / pentane / 0.25 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: cesium fluoride; bis-triphenylphosphine-palladium(II) chloride / methanol / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; sodium hydride; cesium fluoride; 4,4'-di-tert-butyl-2,2'-bipyridine; In methanol; N,N-dimethyl-formamide; pentane; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tetlet.2012.10.034

Reference yield:

: tert-butyl 4-(2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate

: 1415312-41-2
tert-butyl 4-(4-(3-(methoxycarbonyl)-4-methylphenyl)-2H-1,2,3-triazol-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / pentane / 0.25 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: cesium fluoride; bis-triphenylphosphine-palladium(II) chloride / methanol / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; cesium fluoride; 4,4'-di-tert-butyl-2,2'-bipyridine; In methanol; pentane; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tetlet.2012.10.034