N'-{3-cyano-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-pyridin-2-yl}-3,3,3-trifluoropropanehydrazide

Base Information

Chemical Name:N'-{3-cyano-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-pyridin-2-yl}-3,3,3-trifluoropropanehydrazide
CAS No.:1403598-33-3
Molecular Formula:C₂₁H₂₁F₄N₅O₂
Molecular Weight:451.424
Hs Code.:

Synonyms:N'-{3-cyano-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-pyridin-2-yl}-3,3,3-trifluoropropanehydrazide

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Chemical Property of N'-{3-cyano-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-pyridin-2-yl}-3,3,3-trifluoropropanehydrazide

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Technology Process of N'-{3-cyano-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-pyridin-2-yl}-3,3,3-trifluoropropanehydrazide

There total 7 articles about N'-{3-cyano-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-pyridin-2-yl}-3,3,3-trifluoropropanehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 41463-83-6
3,3,3-trifluoropropanoyl chloride

: 1403598-32-2
4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-2-hydrazinopyridine-3-carbonitrile

: 1403598-33-3
N'-{3-cyano-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-pyridin-2-yl}-3,3,3-trifluoropropanehydrazide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm300912k

Reference yield:

: 1403598-31-1
2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile

: 1403598-33-3
N'-{3-cyano-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-pyridin-2-yl}-3,3,3-trifluoropropanehydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / tetrahydrofuran / 0.25 h / 160 °C / Microwave irradiation

2: triethylamine / dichloromethane / 0 - 20 °C

With triethylamine; hydrazine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm300912k

Reference yield:

: 1403598-30-0
4-(3-fluoro-2-methoxyphenyl)piperidine hydrochloride

: 1403598-33-3
N'-{3-cyano-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-pyridin-2-yl}-3,3,3-trifluoropropanehydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.08 h / 0 - 20 °C

2: hydrazine / tetrahydrofuran / 0.25 h / 160 °C / Microwave irradiation

3: triethylamine / dichloromethane / 0 - 20 °C

With sodium hydride; triethylamine; hydrazine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300912k